Ribophagy

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Modelling

Ubp3 & Rsp5

Whi2

Whi2 as a multicopy suppressor of a temperature sensitive mutant of RSP5, which is involved in ribophagy together with Ubp3. If we assume, that a defect in ribophagy, as an essential homeostasis pathway, is responsible for lethality of delta rsp5 mutants, the rescued could be explained by Whi2 multicopy-induced increased STRE gene expression and subsequent overexpression of bulk autophagy or other ribophagy associated proteins. A likely protein candidate in this context would be Ubp3, as it is also involved in ribophagy, cooperatively with Rsp5 controlling the ubiquitinylation state of ribosomes. To test this hypothesis, it could be looked up, whether Ubp3 contains a STRE promotor.

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